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Here's a painting I like. It's one of the outside panels of the Isenheim Altarpiece by Matthias Grunewald, housed at the Unter-den-linden museum in Colmar, Alsace. It's a depiction of St. Anthony, who is known for being one of the first monks to go out into the wilderness to live a holy life. Here he is being beset by demons.
The altarpiece was created for a church that was a site of pilgrimage for people suffering from St. Anthony's Fire, now known as ergotism poisoning; it's a painful, disorienting disease that can cause seizures, itching, psychosis, gangrene, and gastro symptoms. I like the 16th century monsters.